Abasaglar Kwikpen SC Injection 100IU/ml

✔️ Uses of Abasaglar Kwikpen SC Injection 100IU/ml

• Treatment of diabetes mellitus.

✔️ How to use Abasaglar Kwikpen SC Injection 100IU/ml

Increased Protein Synthesis and Glucose Uptake: Insulin helps facilitate the uptake of glucose (sugar) from the bloodstream into cells, especially muscle and fat cells. This uptake is essential for cells to use glucose as a source of energy. Insulin also promotes protein synthesis in these cells, aiding in their growth and repair.

Insulin Receptor Binding: Insulin binds to specific receptors on the surface of muscle and fat cells. This binding triggers a series of intracellular events that promote the movement of glucose transporters (GLUT4) from the cell interior to the cell membrane. These transporters facilitate the transport of glucose into the cells.

Inhibition of Glucose Output from the Liver: Insulin also acts on the liver to suppress its production of glucose. Normally, the liver can release glucose into the bloodstream, helping to maintain blood sugar levels. However, insulin inhibits this process, ensuring that excess glucose is not released into the bloodstream.

By regulating these processes, Abasaglar Kwikpen SC Injection 100IU/ml helps lower blood glucose levels and maintain them within a healthy range. It's important for individuals with diabetes, whose bodies may have difficulty producing or using insulin effectively, to use medications like Abasaglar Kwikpen SC Injection 100IU/ml One to support proper blood sugar control.

✔️ Side Effects of Abasaglar Kwikpen SC Injection 100IU/ml

• Hypoglycemia (low blood glucose stage)
• High blood pressure
• Peripheral edema
• Diarrhea
• Urinary tract infection
• Auto-antibody formation
• Backache
• Upper breathing tract infection
• Cataract

✔️ Quick Suggestions:

• Insulin Glargine is a subcutaneously injected medication. It should be injected once daily, consistently at the same time each day.
• Injecting into the abdomen allows for quicker absorption compared to other sites.
• To prevent the development of hard lumps at a single site, regularly rotate injection locations.
• Maintain a healthy lifestyle by exercising, following a balanced diet, and taking other prescribed diabetes medications.
• Hypoglycemia (low blood sugar) is a common side effect. Monitor blood sugar levels regularly while on this medication.
• Carry high-sugar foods like sugar candy, glucose candy, fruit juice, or glucose to manage hypoglycemia symptoms, such as cold sweats, pale skin, tremors, weakness, and anxiety.
• Opened vials/cartridges are stable at room temperature for up to 4 weeks. Unopened vials should be refrigerated (2°C–8°C).
• Do not use it if the solution is no longer clear and colorless or if it contains particles.

✔️ Indication of Abasaglar Kwikpen SC Injection 100IU/ml

Insulin Glargine is used in the treatment of Diabetes mellitus (Type 1 & Type 2).

✔️ Pharmacology

Nature and Usage: Insulin glargine is a sterile solution used for subcutaneous injection. It's a long-acting insulin analog used to lower blood sugar levels. It's typically administered through injections under the skin.

Recombinant Human Insulin Analog: Insulin glargine is a synthetic form of insulin produced using recombinant DNA technology. It's designed to mimic human insulin but with modifications that lead to a longer duration of action.

Long-Acting Blood Sugar Lowering: Insulin glargine has a prolonged duration of action, often lasting up to 24 hours. This extended effect makes it suitable for providing basal insulin coverage, helping to maintain stable blood sugar levels throughout the day and night.

Regulation of Glucose Metabolism: Insulin glargine's primary function is to regulate glucose metabolism in the body. It helps to manage blood sugar levels by facilitating the uptake of glucose into peripheral tissues like skeletal muscle and fat cells.

Peripheral Glucose Uptake: Insulin and its analogs stimulate the uptake of glucose by cells in the body, primarily muscle and fat cells. This process helps cells use glucose as an energy source and reduces the amount of glucose circulating in the bloodstream.

Inhibition of Hepatic Glucose Production: Insulin glargine also works to inhibit the liver's production of glucose. The liver naturally releases glucose into the bloodstream, but insulin's action on the liver helps prevent excessive glucose release and contributes to blood sugar control.

Additional Effects: Insulin also has other effects, including inhibiting lipolysis (breakdown of fats) and proteolysis (breakdown of proteins) and promoting protein synthesis. These actions contribute to overall metabolic regulation and help maintain the body's energy balance.

✔️ Dosage & Administration of Abasaglar Kwikpen SC Injection 100IU/ml

Adult Dose:

• For Type 1 Diabetes: Start with approximately one-third of total daily insulin requirements; supplement with short-acting insulin for the rest.
• For Type 2 Diabetes: Starting dose for those not on insulin is 10 units (or 0.2 units/kg) once daily.
• Dosage is adjusted based on blood glucose levels.
• When transitioning from other insulins to insulin glargine, adjustments may be needed.

Child Dose:

• For Type 1 Diabetes in children:
  • <6 years: Safety and efficacy not established.

6 years: Start with one third of total daily insulin requirements supplemented with rapid-acting or short-acting insulin for the rest.

Renal Dose:

• Dose adjustments may be necessary for individuals with renal impairment.

General Considerations:

• Insulin glargine exhibits a relatively constant glucose-lowering profile over 24 hours.
• Can be administered at any time during the day, but consistently at the same time daily.
• Dosing should be tailored to the individual's response, with blood glucose monitoring being essential.
• Injection sites should be rotated to reduce the risk of lipodystrophy.
• Absorption and action onset/duration can be affected by various factors, such as exercise, stress, illness, and changes in other medications or meal patterns.

Administration:

• Administer subcutaneously in the upper arm, thigh, or abdominal wall.
• Faster absorption occurs when injected into the abdominal wall.
• Do not administer intravenously (IV) or via an insulin pump to avoid severe hypoglycemia.

It's important to note that this information is a guideline and should be followed under the supervision and guidance of a healthcare provider. Dosage adjustments and usage may vary based on individual needs and medical conditions. If you have any questions about your medication or its administration, consult your healthcare provider.

✔️ Interaction

Interaction with Other Medications:

• Low Blood Sugar Symptoms: If you are taking other medicines for diabetes, depression (fluoxetine), fever and pain (salicylates), ramipril, or lisinopril, you may experience symptoms of low blood sugar (hypoglycemia).
• High Blood Sugar Symptoms: If you are taking oral contraceptives, thiazide diuretics, steroids, thyroxine, medicines for severe diarrhea, or growth-regulating drugs like octreotide or lanreotide, you may experience high blood sugar levels (hyperglycemia).

Caution with Pioglitazone:

• If you are taking pioglitazone to treat diabetes, be cautious, as there have been reported cases of heart attack and heart failure associated with its use.

Response to Low Blood Sugar:

• Some medications can block your body's usual response to low blood sugar, leading to a lack of typical symptoms like headache, hunger pangs, sweating, and anxiety. This can result in a severe drop in blood sugar. Medications like beta-blockers (metoprolol, propranolol, atenolol), clonidine, guanethidine, and reserpine fall into this category.

Interactions with Food:

• The medicine is to be taken either 15 minutes before meals or after meals.
• Maintaining a consistent meal pattern is recommended when taking insulin.
• Avoid skipping or delaying meals while on insulin to maintain stable blood sugar levels.

These considerations are crucial for ensuring the safe and effective use of insulin glargine and for preventing potential complications related to blood sugar levels and interactions with other medications. As always, it's important to follow your healthcare provider's instructions and consult them if you have any questions or concerns about your medication, its interactions, or your treatment plan.

✔️ Contraindications

• If you are allergic to insulin or any of the ingredients of this medicine
• If you are suffering from hypoglycemia (low blood sugar level).

✔️ Pregnancy & Lactation

Pregnancy:

• Insulin glargine is categorized as Pregnancy Category C.
• Its use during pregnancy should only be considered if the potential benefit to the mother justifies the potential risk to the fetus.
• The decision to use insulin glargine during pregnancy should be made in consultation with a healthcare provider, considering the individual's medical condition and the potential risks and benefits to both the mother and the fetus.

Lactation:

• It's unclear whether insulin glargine is excreted in human milk.
• Since many drugs, including human insulin, can be excreted in breast milk, caution should be exercised when using insulin glargine in nursing women.
• Women who breastfeed while on insulin glargine may require adjustments in their insulin dose and dietary intake to ensure proper blood sugar control for both the mother and the nursing infant.

✔️ Precautions & Warnings

• Abasaglar Kwikpen SC Injection 100IU/ml 3ml is meant for subcutaneous use (under the skin) and should never be administered intravenously (IV) or into the veins.
• Changing insulin brands or administration methods should be done under strict medical supervision.
• Use caution when using pioglitazone in combination with insulin glargine, especially in patients at high risk of heart failure.
• Cases of heart failure have been reported in such cases.
• Early symptoms of high blood sugar levels (hyperglycemia) can include excessive thirst, dry mouth, frequent urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and an acetone odor in the breath.
• Close monitoring of these symptoms is important.
• Symptoms of heart failure, weight gain, and edema (fluid accumulation in tissues) should not be ignored and should be discussed with a healthcare provider.
• It's advisable to avoid alcohol consumption, as it can affect blood glucose levels.
• When traveling across more than two time zones, adjustments to your insulin schedule may be necessary. Consult your doctor for guidance.
• Do not use Abasaglar Kwikpen SC Injection 100IU/ml 3ml if you have low blood glucose levels, kidney, liver, or heart problems, or if you have issues with alcohol or other prescription recreational drugs.
• Insulin glargine may decrease potassium levels, leading to hypokalemia. Severe hypokalemia can result in respiratory paralysis, irregular heart rhythms, coma, and even

✔️ Storage Conditions

• Store between 2°C to 8°C in the refrigerator
• Do not freeze it
• Keep it out of the reach of children
• Do not open the carton of vials to protect it from light
• Any unused portion should not be stored and should be appropriately discarded.